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project:brain_hacking:memory [2012/09/29 19:32]
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project:brain_hacking:memory [2012/09/29 22:43] (current)
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  {{http://media.tumblr.com/tumblr_m560ubNTEW1qcd31o.jpg}}  {{http://media.tumblr.com/tumblr_m560ubNTEW1qcd31o.jpg}}
  
-==== Final goal: ====+===== Final goal: =====
   * specific memory modification ,errasing   * specific memory modification ,errasing
  
-==== Planned usage: ====+===== Planned usage: =====
   * post traimatic stress disorder, phobia   * post traimatic stress disorder, phobia
  
-==== Progress: ====+===== Progress: =====
   * studing basic info    * studing basic info 
  
-==== Metods: ====+===== Metods: =====
  
-==== Testing: ====+===== Testing: =====
   *EEG,EKG,GSR   *EEG,EKG,GSR
  
  
-==== Notes: ====+===== Notes: =====
 {{youtube>Mu59KU2RyYs?medium}} {{youtube>Mu59KU2RyYs?medium}}
  
-===PKMζ===+====PKMζ====
 source:[[http://en.wikipedia.org/wiki/Protein_kinase_M_zeta/Protein_kinase_C_zeta]] source:[[http://en.wikipedia.org/wiki/Protein_kinase_M_zeta/Protein_kinase_C_zeta]]
  
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   *When we remember something, our memories once again enter a fragile state when they can be edited or overwritten – is this because PKMzeta must be destroyed and created afresh? How does newly formed PKMzeta manage to find synapses that are already tagged with this protein? What stops all the neurons in our brain from becoming saturated with PKMzeta? How does sleep affect the levels of PKMzeta at synapses? And does the memory engine start having problems as we grow older?   *When we remember something, our memories once again enter a fragile state when they can be edited or overwritten – is this because PKMzeta must be destroyed and created afresh? How does newly formed PKMzeta manage to find synapses that are already tagged with this protein? What stops all the neurons in our brain from becoming saturated with PKMzeta? How does sleep affect the levels of PKMzeta at synapses? And does the memory engine start having problems as we grow older?
  
 +source:[[http://blogs.discovermagazine.com/notrocketscience/2011/03/03/todd-sacktor-talks-about-the-memory-engine/]]
 +  *by injecting an inhibitor of PKMzeta called **ZIP** into the brains of lab rats. That erased the memories that were stored in that part of the brain, even for learning that had happened months before and even for really strong memories.
 +  *consolidation of memory – the transition from short to long-term memory. That’s not just one molecule, it’s hundreds, with many parts of the brain working in concert. There’s a transition period for an hour or two after you learn something when it’s not consolidated and when it’s easy to prevent it from doing so. Adding the modern view from our research onto this, we’d say that it’s easy to prevent the synthesis of PKMzeta, but once you make it, the memories become consolidated at specific synapses.
 +  *It’s likely that the reconsolidation is blocking the resynthesis of PKMzeta.
  
-===Reconsolidation window ===+ 
 +====Reconsolidation window ====
 source:[[http://blogs.discovermagazine.com/notrocketscience/2011/01/26/an-injection-and-a-nap-two-ways-of-strengthening-memories/]] source:[[http://blogs.discovermagazine.com/notrocketscience/2011/01/26/an-injection-and-a-nap-two-ways-of-strengthening-memories/]]
   *Until you save the file, there’s a chance that you could lose the information. This vulnerable window can last for a couple of days. Only after that point does the memory become strong and long-lasting. This is called ‘consolidation’.   *Until you save the file, there’s a chance that you could lose the information. This vulnerable window can last for a couple of days. Only after that point does the memory become strong and long-lasting. This is called ‘consolidation’.
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     * only promising drug, the** beta-blocker propanolol** ( By giving propanolol to people before they recalled a scary spider memory, Kindt could erase the fearful response it triggered. )     * only promising drug, the** beta-blocker propanolol** ( By giving propanolol to people before they recalled a scary spider memory, Kindt could erase the fearful response it triggered. )
  
-===Propanolol===+====Propanolol====
 source:[[http://blogs.discovermagazine.com/notrocketscience/2009/02/16/beta-blocker-drug-erases-the-emotion-of-fearful-memories/]] source:[[http://blogs.discovermagazine.com/notrocketscience/2009/02/16/beta-blocker-drug-erases-the-emotion-of-fearful-memories/]]
   *propranolol, commonly used to treat high blood pressure and prevent migraines in children   *propranolol, commonly used to treat high blood pressure and prevent migraines in children
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   *effect is amygdala specific   *effect is amygdala specific
                    
 +====CREB====
 +source:[[http://blogs.discovermagazine.com/notrocketscience/2009/03/12/erasing-a-memory-reveals-the-neurons-that-encode-it/]]
 +  *Han’s found that a protein called CREB is a molecular beacon that singles out neurons involved in remembering fearful experiences. When a rat experiences something scary, the CREB-neurons in a part of its brain called the amygdala are responsible for storing that memory – for producing what neuroscientists call its “trace”. When Han killed the amygdala’s CREB-neurons, he triggered selective amnesia in the rats, abolishing the specific fears they had been trained to feel. The memory loss was permanent. 
 +  *Previously, Han showed that neurons in the amygdala are recruited to form part of a new memory trace depending on how much CREB they have. He bolstered the amount of this vital protein in a small group of neurons and found that, compared to their normal neighbours, these CREB-enhanced cells were three times more likely to be activated when he trained rats to fear a musical tone. Neurons that lacked CREB altogether were 12 times less likely to be activated when rats learned to be scared. 
  
  
-http://blogs.discovermagazine.com/notrocketscience/2009/03/12/erasing-a-memory-reveals-the-neurons-that-encode-it/ 
 
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