|1930 - meetup 1900 Ron Minnich: The coreboot project|
|1930 Petr Tomek: Perspektivní pohony mezihvězdných lodí|
|1900 BRMCW - vyuka telegrafie|
CES Ultra Primary Specifications
Biedebach12 has argued that treatment efficacy is determined by certain microcurrent waveform parameters. Research suggests that N-type voltage-sensitive calcium channels in cell membranes are more effectively opened by short electrical pulses.13 Other work suggests that L-type voltage-sensitive calcium channels are more effectively opened by longer pulses.14 N-type channels tend to predominate on sensory neurons and stimulate the release of powerful vasodilating substances such as calcitonin gene-related peptide, whereas L-type channels predominate on fibroblasts.15 Theoretically, it would be advantageous for a microcurrent device to incorporate both characteristics into its waveform, and to adjust each component in response to changing tissue electrical impedance in an attempt to optimize the effect. One microcurrent device (Figure 1) addresses this issue.16 The current waveform (Figure 2) has an “overshoot” phase, which acts as a short-duration pulse to open N-type channels, and a longer duration “plateau” phase to open L-type channels. In 1 model, the current overshoot is maintained between 1.5 and 2.0 mA. The width of the overshoot (measured at the 1.0-mA level) is automatically adjusted between 100 and 300 microseconds by a feedback mechanism in response to the measured tissue impedance. The width of the overshoot increases with decreasing tissue impedance; this is believed to open more N-type channels. The plateau phase width is automatically adjusted between 2 and 200 milliseconds commensurate with tissue impedance in an attempt to optimize the opening of L-type channels. The amplitude of the plateau phase is determined predominantly by the manually adjusted intensity dial on the outside of the device. A train of positive-going “carrier pulses” is followed by a train of negative-going carrier pulses to complete a 4-second repeating cycle (Figure 3). The carrier pulse frequency is adjusted manually by the frequency dial. Treatment is rendered by use of attachable electrodes including (but not limited to) brass “mini plates,” “point-specific probes” with brass tips, “transcranial clip” (earclip) electrodes, and an “auricular probe” with a thin, spring-loaded, stainless steel tip for the detection and treatment of auricular points (Figure 4).
Variace CES Ultra